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br Analytical improvements Since our review of Oxysterol Met
2021-02-09
Analytical improvements Since our review of “Oxysterol Metabolomes” in 2011 [7], there have been a number of improvements in analytical methods for the analysis of oxysterols and related compounds. McDonald and colleagues in Dallas have refined their LC-MS methods which are now applicable for ana
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As before all calculations are based on thermodynamically fi
2021-02-09
As before [3], [4], all calculations are based on thermodynamically first- and second-order hydropathic (amino acid) scales [6], [7], linearly scaled to a common center and a common range for each of the 20 amino acids. These are then converted to a triangular matrix , where is the length of a s
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DAPK is involved in the
2021-02-08
DAPK-1 is involved in the p53 dependent apoptotic pathway and it is a mediator of γ-interferon induced apoptosis. DAPK-1 is also involved in other death signaling pathways (tumor necrosis factor-α, CD95 and transforming growth factor-β) and it blocks tumor metastasis in vivo. The loss of DAPK mRNA E
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br Conflict of interest br Acknowledgments
2021-02-08
Conflict of interest Acknowledgments We thank Jianru Zuo (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China) for providing fbr11-1 seeds. We are grateful to Carol MacKintosh and the DSTT at the University of Dundee (UK) for anti-RD21 antibodies. This
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DASA-58 br Acknowledgement This study was supported
2021-02-08
Acknowledgement This study was supported by Vetenskapsrådet, Sweden (Grant 2017-02918). Introduction Soybean is a major source of protein and oil used for food and feed, as well as for the production of industrial products like lubricants and hydraulic fluids (Choudhary and Tran, 2011; Hsien,
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Opiate withdrawal promotes the activation of the corticotrop
2021-02-08
Opiate withdrawal promotes the activation of the corticotropin-releasing factor (CRF) system, a major coordinator of neuroendocrine and behavioral responses to stressors. For instance, early (8–48 h) morphine withdrawal is associated with increased CRF mRNA expression in the central nucleus of the a
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The binding pattern of was analysed by flexible molecular
2021-02-08
The binding pattern of 1 was analysed by flexible molecular docking. The Rigosertib inserted into the narrow ATP binding site of CK2 (Fig. 2). As shown the aliphatic chain of 1 was located at the edge of the pocket and established van der Waals interactions with the side chains residues of Ile95, Me
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Accumulated evidence indicates that apelin plays a protectiv
2021-02-08
Accumulated evidence indicates that apelin plays a protective role in ischemic stroke, contributing to post-stroke recovery (Yang et al., 2014; Chen et al., 2015; Xin et al., 2015; Yan et al., 2015). Apelin gene (APLN) encodes prepro-apelin with 77 amino acids, while the C-terminal 23 5α-dihydro-11-
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br Acknowledgments br Casein kinases CK are serine threonine
2021-02-08
Acknowledgments Casein kinases (CK) are serine/threonine-specific enzymes and can be divided two subtypes: casein kinase 1 (CK1) and casein kinase 2 (CK2). CK1 contains at least seven isoforms (α, β, γ1, γ2, γ3, δ and ε) expressed in eukaryotic organisms, CK1 is involved in various cellular pro
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br Membrane receptor Indirect non genomic signaling
2021-02-08
Membrane receptor: Indirect non-genomic signaling As mentioned above, not all Zanamivir responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be acting by
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Exposure to UV instead of DMBA also produced
2021-02-08
Exposure to UV instead of DMBA also produced a sloughing and angiogenic response in transgenic, but not WT, mice, indicating that the epidermis of the BK5.EP4 mice has a much lower apoptosis threshold than WT mice, as suggested by others (Chun and Langenbach, 2007). Overall, these studies suggest th
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In summary we investigated the fluoride sensitivity of
2021-02-08
In summary, we investigated the fluoride sensitivity of different S. mutans strains in terms of enolase activity. Lower enolase activity was not always associated with lower S. mutans growth in cultures with NaF. Gene analysis showed that UA130 and NCH105 both have enolase point mutations. Unique am
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It is believed that emphysema in smokers
2021-02-08
It is believed that emphysema in smokers is mediated by proteases released from inflammatory Cy5 TSA that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysematous lesions in e
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The significance of the difference in the
2021-02-08
The significance of the difference in the DDR2 binding specificity towards fibrillar and non-fibrillar collagens is not understood, but may imply differences in biological responses when chondrocytes bind to different collagens in the growth plate. Investigations by Labrador et al. (2001) have shown
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One architecture termed closed has been visualized at
2021-02-08
One architecture, termed closed, has been visualized at near-atomic resolution in cryo-EM maps of recombinant complexes that superimpose with earlier lower-resolution EM data obtained for APC/CCDC20–MCC purified from HeLa Tranilast arrested during the mitotic checkpoint (Figure 4E) 38, 48, 51. Here
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