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Electron transport via DHODH activity will allow the generat
2021-02-03
Electron transport via DHODH activity will allow the generation of mitochondrial ROS without the consumption of α-ketoglutarate or NADH. Glutamine-dependent flux through the TCA cycle and oxidative phosphorylation can also enable generation of mitochondrial ROS (Weinberg et al., 2010). The latter pr
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br DDR in atherosclerosis and vascular disease The Canadian
2021-02-03
DDR1 in atherosclerosis and vascular disease The Canadian group of Bendeck, explored the role of DDR1 in repair following arterial injury in rats [30]. DDR1 protein levels, assessed via Western blots prepared from arterial extracts taken at various times after injury, showed DDR1 protein dramatic
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Arsenic could cause apoptosis in
2021-02-03
Arsenic could cause apoptosis in both benign and malignant cells (Akao et al., 2000, Gupta et al., 2003, Namgung and Xia, 2001). However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins. In addition, the alter
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N fowleri enters the host through the nasal cavity and
2021-02-03
N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the determining molarity where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immune system but also elicits exte
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Because aspirin and ibuprofen are NSAIDs both
2021-02-03
Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, letrozole cost sale and cerebral microbleeds [13]. Moreover, both cause liver damage [10]. Laster [14] reported a patient with pericarditis treated wi
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br Materials and methods br Results br Discussion In the
2021-02-03
Materials and methods Results Discussion In the present study, as a trial to evaluate the marine ciliate E. crassus for further studies, its susceptibilities to B[a]P and β-NF were measured. Acute toxicity of B[a]P in aquatic organisms has been extensively studied, but not enough data is av
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Liver metabolic programming begins in utero Aiming to find a
2021-02-03
Liver metabolic programming begins in utero. Aiming to find a reason for the decreased lipid catabolism enzyme expression observed in fetuses and offspring from SFD rats, we studied the effect of leptin on liver catabolism in fetuses from control and SFD rats. Livers from control fetuses responded t
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The most important cytotoxic lesion formed by the nitrogen
2021-02-03
The most important cytotoxic lesion formed by the nitrogen mustards is generally considered to be the DNA–DNA interstrand cross-link 12, 13. DNA–DNA interstrand cross-links are thought to exert their cytotoxic effects by inhibiting DNA duplex strand separation, progression of the estrogen receptor a
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br Experimental section br Results br Discussion In our prev
2021-02-03
Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised AG-1024 did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by al
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Following the relationship model adopted
2021-02-03
Following [20], [22], the relationship model adopted in this 98 5 australia work to estimate the time to failure is the Inverse Power Law (IPL): Where L is the SUT life characteristic (e.g. the mean time to failure), s represents the stress level, while k and w are model-related parameters to be de
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The BDNF Val Met polymorphism is also associated
2021-02-03
The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is co
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It should be noted that the
2021-02-03
It should be noted that the long-lifetime binding-responsive luminescence of ARC-1528 and ARC-1530 becomes evident only upon illumination with radiation at near-UV range where the excitation of ATB or ASB moiety is possible. At higher wavelength range (visible light), the fluorophore (5-TAMRA) can b
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Gedunin sale br Acknowledgments This study was supported by
2021-02-03
Acknowledgments This study was supported by grants from the Spanish Ministry of Economy and CompetitivenessPI10/00387, PI12/01087, PI12/01703, IPT-2011-0817-010000, and RIC Red de Investigación Cardiovascular (RIC)RD12/0042/0055. RIC is an initiative of Instituto de Salud Carlos III (ISCIII), Spa
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The crystal structure of full length CHK is still
2021-02-03
The crystal structure of full-length CHK is still unsolved. However, the close homology between CHK and Csk suggests that these kinases share a similar structure. Therefore, the engagement of the CHK SH2–kinase linker with the αC-helix could control the activity of the CHK kinase domain. Sequence al
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Additionally both in vitro and in vivo studies showed
2021-02-03
Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bindi
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