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CCR is another chemokine receptor
2021-06-25
CCR7 is another chemokine receptor that is upregulated in CLL [3], [61], [71], [96] and is believed to play a role in enabling cell entry into lymph nodes [97]. Higher mRNA and protein expression of CCR7 has been observed in unmutated compared to mutated IGHV CLL [46] and increased expression has be
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br STAR Methods br Author Contributions br
2021-06-25
STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer
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Although DGK is a lipid modulating enzyme the
2021-06-25
Although DGKγ is a lipid-modulating enzyme, the role of DGKγ in integral cell metabolism has not been reported. We found that DGKγ made a difference on cell metabolism profile in HCC cells, which may be caused partially by the downregulation of GLUT1. Glucose is a major source of energy, and decreas
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br Methods br Results and discussion
2021-06-25
Methods Results and discussion Acknowledgements Introduction Diacylglycerol O-acyltransferase (DGAT) is a key enzyme that catalyzes the final committed step in triglyceride synthesis and is highly expressed in the small intestine, adipose tissue, liver and mammary gland.1, 2, 3, 4 Its im
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br Materials and methods br
2021-06-24
Materials and methods Results Discussion Recently it has been found that prostaglandins play an important role in modulating the host immune system [1,3,22,23], and some parasites produce these eicosanoid mediators to survive into their hosts [6,[10], [11], [12],24,25]. The discovery that p
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We found all cases to show at
2021-06-24
We found all cases to show at least some IGF-1R expression by immunohistochemistry. This is consistent with its ubiquity at the mRNA or protein level in ES/PNET cell lines or clinical samples as shown by others.12, 14 Evidence that IGF-1R expression is required for EWS-FLI1 transformation of mouse f
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The nitrophenols b d were prepared as
2021-06-24
The nitrophenols 34b–d were prepared as described in Scheme 3b. Nitration of phenols 39b–d with 1equiv of sodium nitrate in the presence of hydrochloric ap1 gave an inseparable mixture of 34b–d and 40b–d (1:1). This synthetic problem was successfully avoided as described below. Nitration of 39b–d w
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aurora a australia br Materials and methods F philippinensis
2021-06-24
Materials and methods F. philippinensis plants were collected in August 2014 at a farm in Ninning, Guangxi province, China and identified by Dr. Yimmin Zhao. Voucher specimens (No. 530) were deposited in the Herbarium of Gaunxi Botanical Garden, China. Human recombinant neutrophil elastase (EC 3.
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br Acknowledgements The present study was supported
2021-06-24
Acknowledgements The present study was supported by the Medical Science and Technology Program of Zhejiang Province2014KYA228 (Zhijun Zhou), 2016KYA195 (Jie Li) and 2017KY714 (Qingqing Xia); Zhejiang Provincial Natural Science Foundation of ChinaQ17H120001 (Jie Li); and Scientific Research Projec
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The pseudo DUBs KIAA and Abraxas are required for
2021-06-23
The pseudo DUBs KIAA0157 and Abraxas are required for the catalytic function of BRCC36. Comparison of the BRCC36–KIAA0157 heterodimer structure with an inactive BRCC36 homodimer structure provides a model for understanding how this functional interplay is achieved. As shown in schematic form in Figu
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EHNA hydrochloride br Conclusion br Acknowledgments br Intro
2021-06-23
Conclusion Acknowledgments Introduction Arsenic (As) is one of the most toxic metals derived from the natural environment in soil, air and well water. It has two oxidative states: a trivalent form, arsenite, and a pentavalent form, arsenate. The inorganic As is more toxic than organic As. A
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Cyanine 5-dUTP mg Whether a school is private
2021-06-23
Whether a school is private or public may also be an indicator of its quality. In general, private schools have smaller class sizes which may provide a better learning environment. Lindquist and Smith (2013) state that smaller class sizes provide more opportunities for students to interact with prof
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The BDNF Val Met polymorphism is
2021-06-23
The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is co
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The present study was the first to
2021-06-23
The present study was the first to examine how COMT genotype and estradiol are associated with sesamin sale functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would remain and perhaps bec
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So what can we glean
2021-06-23
So what can we glean from this illuminative foray into how Chk1 and MK2 participate in checkpoint control? First and foremost, this work reveals that D4476 deficient in the tumor suppressor p53 contain two spatially distinct G2/M phase checkpoint control kinase networks. This provides compelling ev
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