• br Methods br Results br Discussion The aim of

  2022-03-23

  

  Methods Results Discussion The aim of this study was to investigate whether serum lectin-binding activity is associated with development of HCC in HCV-positive individuals. Using ELISA-based assays of lectin-binding activity, we demonstrated that both age and gender influence the circulatin

• It has been proposed that HCA may be a

  2022-03-23

  

  It has been proposed that HCA1 may be a better target than HCA2 to treat dyslipidemia and to prevent progression of atherosclerosis, because HCA1 is less widely expressed, and HCA1 activation does not result in flushing. However, since the antilipolytic effects mediated by HCA2 appear to be not the

• While PLGA implants could be beneficial

  2022-03-23

  

  While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they Isotretinoin could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, which might h

• Over expression of Glo can suppress inflammatory responses M

  2022-03-22

  

  Over-expression of Glo-1 can suppress inflammatory responses. Methylglyoxal mediates vascular inflammation in human endothelial Gemfibrozil synthesis [33], indicating that Glo-1 may attenuate inflammation via eliminating methylglyoxal. Glo-1 knockdown mediated methylglyoxal accumulation provokes co

• EAAT glutamate uptake is driven

  2022-03-22

  

  EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit aminolevulinic acid of glutamate into the cell against a steep concentration gradient

• A oligomers increased ubiquitination of GLT in astrocytes

  2022-03-22

  

  Aβ1-42 oligomers increased ubiquitination of GLT-1 in astrocytes. Previous studies found that astrocytic GLT-1 is internalized from the cell surface by ubiquitination of lysines located in the cytoplasmic C-terminus of the transporter (Gonzalez-Gonzalez et al., 2008, Martinez-Villarreal et al., 2012

• Importance of glucokinase in glucose homeostasis and a possi

  2022-03-22

  

  Importance of glucokinase in glucose homeostasis and a possibility to change its activity using the activators define the scientific interest in the development of new allosteric activators of GK (Liu et al., 2012, Pfefferkorn et al., 2011, Waring et al., 2013, Behera et al., 2015). Activation of gl

• Genetic disruption or pharmacologic inhibition of the hepati

  2022-03-22

  

  Genetic disruption or pharmacologic inhibition of the hepatic glucagon pathway has invariably been shown to increase pancreatic α cell mass. This has been observed in glucagon receptor (GCGR) knockout (Gcgr−/−) mice (Gelling et al., 2003), glucagon knockout mice (Hayashi et al., 2009), prohormone co

• The presented results speak for

  2022-03-22

  

  The presented results speak for the direct effects of ghrelin on rat spermatozoa, which are accomplished by the activation of the GHSR-1a receptor. Thus, the results seem to be of physiological significance in vivo since ghrelin, the natural ligand of GHSR-1a, was found to be present in the seminal

• In a follow up study the same research group

  2022-03-22

  

  In a follow up study, the same research group further characterized FFA4 involvement in DU145 and PC-3 cancer cell lines by demonstrating that the anti-proliferative and anti-migration activities of FFA4 require the presence of LPA1 receptor (LPA1R), suggesting a mechanism consistent with negative c

• Previous research has suggested that

  2022-03-22

  

  Previous research has suggested that differences in spatiotemporal regulation of intracellular signaling pathways can confer specificity to cellular responses (Marshall, 1995). Conventional approaches based on gain- or loss-of-function genetic manipulations or small-molecule inhibitors, however, la

• 155 8 Based on the above presumption activation of Sox

  2022-03-22

  

  Based on the above presumption, activation of Sox11 and FAK might be beneficial for alleviating the VILI. Previous studies have showed the relevance of Sox11 or FAK up-regulation with improvement of tissue injury. For example, over-expression of Sox11 protected and improved the tissue function or st

• The finding of histamine action on ASICs also raises the

  2022-03-22

  

  The finding of histamine action on ASICs also raises the question about possible action of other histamine receptor ligands. In the present work we selected several compounds and performed electrophysiological testing of their action on recombinant homomeric ASIC1a and ASIC2a. Nα-methylhistamine is

• Allergic rhinitis characterized by inflammation of the nasal

  2022-03-22

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to Capecitabine sale in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering alle

• br Author contributions br Declaration of conflict of intere

  2022-03-22

  

  Author contributions Declaration of conflict of interest Acknowledgements We are grateful to the Director, National Institute of Immunology for his support. The work was partially supported by J.C. Bose Fellowship to SSM. We acknowledge the help from staff of Small Animal Facility of Nation

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