• It was previously demonstrated that dissociation of the V

  2025-02-07

  

  It was previously demonstrated that dissociation of the V-ATPase in response to glucose depletion in yeast requires an intact microtubular network [28] and a catalytically active enzyme [29]. Interestingly, mutations in the non-homologous region of the catalytic subunit A are able to block dissociat

• Human leukemic blasts from both AML

  2025-02-07

  

  Human leukemic blasts from both AML and ALL patients demonstrated 5-, 12-, and 15-LOX expression [54]; however, using quantitative PCR, 5-LOX was much more prevalent than 15-LOX. When 15-HETE, 12-HETE, and LTB4 were tested for a direct effect on leukemic blasts, none induced apoptosis [54]. In contr

• The amino hydroxy methyl isoxazolepropionic

  2025-02-07

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Tanzisertib (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roche, 2012

• From an historical perspective ligands for GPCRs adrenaline

  2025-02-07

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, Cholestasis treatment or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous l

• choline fenofibrate Activated MAP kinases transform the

  2025-02-07

  

  Activated MAP kinases transform the stimulus into the pathophysiological responses by phosphorylating downstream substrates, including transcription factors, cytoskeletal proteins involved in mRNA translation (Li et al., 2015). Among the numerous effectors that intervene in the TNF-α action is an ac

• br Conclusions br Author declaration br Acknowledgements br

  2025-02-07

  

  Conclusions Author declaration Acknowledgements Introduction ASK1 scaffolding proteins ASK1 adaptor proteins Conclusions Scaffolding and adaptor proteins can coordinate the specific activation of a MAP3K-MAP2K-MAPK pathway in response to various stimuli. For example, both Cancer

• Antioxidative enzymes such as SOD

  2025-02-07

  

  Antioxidative enzymes such as SOD and CAT play prominent roles in protecting against oxidative stress and extending food freshness due to their ability in scavenging active oxygen species for maintaining cell membrane integrity. Evidence shows that activities of SOD and CAT are positively affected b

• This study evaluated the anti tumor influences

  2025-02-07

  

  This study evaluated the anti-tumor influences of LA against HepG2 Manumycin A in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochondrial-m

• F is an orotomide a novel class of

  2025-02-07

  

  F901318 is an orotomide, a novel class of antifungals, which inhibits pyridine biosynthesis by blocking dihydroorotate dehydrogenase (URA1) activity [137]. Although this pathway is conserved in humans, human URA1 is only 20% identical to its fungal homolog and it is inhibited 2000-fold less effectiv

• To further evaluate the influence of antibiotics on

  2025-02-07

  

  To further evaluate the influence of ACP-196 on allergy, Russel et al. initiated vancomycin treatment during pregnancy in mice and continued it for several weeks after birth. This resulted in exaggerated OVA-induced allergic inflammation, characterized by higher numbers of lung eosinophils, elevate

• Another hypothesis is angiogenesis inhibition Angiogenesis i

  2025-02-07

  

  Another hypothesis is angiogenesis inhibition. Angiogenesis is a process that involves the growth, migration and differentiation of endothelial Long-term potentiation inhibitor to form new blood vessels. Angiogenesis favorably influences tumor growth and also influences tumor invasion of vessels, r

• Pathological angiogenesis occurs when an imbalance of endoge

  2025-02-07

  

  Pathological angiogenesis occurs when an imbalance of endogenous proangiogenic and antiangiogenic factors occurs. Although the focus of angiogenesis-related drug development has been geared to the discovery of antiangiogenic compounds for use in pathologies where excessive angiogenesis occurs (cance

• Introduction Cardiovascular disease is the principal

  2025-02-07

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with L-Glutathione Reduced (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardi

• ALK fusion positive NSCLC is clinically actionable because i

  2025-02-07

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• Structure activity relationships biochemical metabolic and m

  2025-02-06

  

  Structure–activity relationships [23], [24], [25], [26], biochemical [24], [25], [26], [27], [28], [29], [30], [31], metabolic [19], [27], [28], [29], [30], [31], and molecular [32] investigations have demonstrated that the substrate specificity, as well as other characteristics of T. gondii adenosi

15305 records 19/1021 page Previous Next First page 上5页 1617181920 下5页 Last page