• QSAR based on the D structures of ligands plays an

  2019-09-02

  

  QSAR based on the 3D structures of ligands plays an important role in the ligand-based drug discovery and design [12]. Comparative molecular field analysis, CoMFA [11], and comparative molecular similarity index analysis, CoMSIA [12] are among the most popular QSAR models. They focus on changes in 3

• These data raised from human tissues suggested

  2019-09-02

  

  These data raised from human tissues suggested a potential link between TGF-β1 signaling and linear invadosome machinery that may explain TGF-β involvement in HCC progression and invasion. Using HCC cultured cells, we confirmed that TGF-β1 stimulation increases the production and secretion of collag

• Cytochromes P CYP are a superfamily of hemoproteins

  2019-09-02

  

  Cytochromes P450 (CYP 450) are a superfamily of hemoproteins containing a heme cofactor, which are widely distributed in animals, plants and microbes (Hannemann et al., 2007). CYP450 exhibits a variety of biological functions including biotransformation of drugs, detoxification of endogenous and xen

• Khan et al investigatedAnomalin a pyranocoumarin constituent

  2019-09-02

  

  Khan et al. investigatedAnomalin 44, a pyranocoumarin constituent of S. divaricata, which exhibits potent anti-inflammatory activity. The anomalin 44 dose-dependently inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein expression in LPS-stimulated RAW 264.7

• br Bipartite graph br Algorithm for CFC

  2019-09-02

  

  Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in sorafenib tosylate from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-1A

• It is interesting that of the control groups female

  2019-09-02

  

  It is interesting that of the control groups, female TG controls only had significantly higher MB-COMT protein than non-TG male controls (Supplemental Table 9, P = 0.005), while these two groups have almost equal expression of S-COMT protein (8.54- vs. 8.34-fold) and their COMT enzyme activity is al

• br Experimental Procedures br Acknowledgments We thank R Bri

  2019-08-30

  

  Experimental Procedures Acknowledgments We thank R. Brink for providing HEL2x, M. Tanaka for CD169DTR mice, R. Lathe for making Cyp7b1+/− mice available, and M. Barnes and A. Reboldi for comments on the manuscript. T.Y. is an Irvington Institute Postdoctoral Fellow at the Cancer Research Insti

• aminoisobutyric acid BAIBA is a natural

  2019-08-30

  

  β-aminoisobutyric oxygenase (BAIBA) is a natural catabolite of the branched-chain amino acid thymine. BAIBA was recently found to reduce inflammation in skeletal muscle via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor (PPAR)δ signaling pathway. BAIBA reportedly

• br Materials and methods br Results br

  2019-08-30

  

  Materials and methods Results Discussion Regardless of obvious beneficial effects of GC on acceleration of foetal lung and cardiomyocytes maturation (Kamath-Rayne et al., 2012; Rog-Zielinska et al., 2015), the current study revealed that GC exposure during late pregnancy induces IR and alte

• Cot MAP K is the

  2019-08-30

  

  Cot (MAP3K8) is the sole MAP3K that activates the MEK1/2-Erk1/2 following the activation of the TLR/IL-1 receptor superfamily as well as some receptors of the TNF receptor family [8], [9], [10] and mediates the production of chemokines and cytokines in different cell systems [reviewed in [11]]. Thus

• Previously we have shown that complexes of protein PKs with

  2019-08-30

  

  Previously, we have shown that complexes of protein PKs with inhibitors that comprised sulfur or selenium atoms in aromatic structures were phosphorescent at room temperature, while the long-lifetime signal emitted by the free inhibitor was negligible.34, 35, 36 This phenomenon was caused by stabili

• Prenylation may turn a flavonoid from an agonist

  2019-08-30

  

  Prenylation may turn a flavonoid from an agonist to an antagonist and improve the selectivity to both ERs depending on the position of the substitution. C-8 prenylation appears to promote antagonism to a larger extent than C-6 in ERα due to steric hindrance against generation of agonistic conformati

• Glycolysis is important to maintain the vital functions of T

  2019-08-30

  

  Glycolysis is important to maintain the vital functions of T. gondi. Extracellular T. gondii shift its Phosphatase Inhibitor Cocktail (2 Tubes, 100X) metabolism towards glycolysis, based on the observation that a relocation of glycolytic enzymes from the cytosol to the pellicle occurs at the time wh

• VMD v Humphrey et al was

  2019-08-30

  

  VMD v1.9.2 (Humphrey et al., 1996) was used to analyze the MD trajectories, salt bridge interactions and secondary structure information from each frame. Once the model was optimized, the topological diagram and area and volume of protein cavities were analyzed using PDBsum (Laskowski, 2009) and CAS

• br Significance Dysregulation of dopamine homeostasis contri

  2019-08-30

  

  Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of AM095 governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitalize on Nurr1

15236 records 1002/1016 page Previous Next First page 上5页 10011002100310041005 下5页 Last page